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Microbiology Fellowship

Company: ORAU Maryland Office
Location: Bedford Park
Posted on: October 19, 2020

Job Description:

Proficiency testing and inter-laboratory studies have a major role in developing and implementing guidelines for Model Laboratory Standards and Accreditation requirements of Food Safety modernization Act (FSMA). FSMA necessitates standardization and validation of microbiological methods. Due to rapidly changing technologies and the vast resources required to validate methods, there is a wide gap in the need for bringing new, reliable methods to the field and the availability of independently (and FDA) validated protocols. Validation of both microbiological and chemical analytical methods used by the FDA is one of the most important expected research outcomes. Validation of analytical methods developed by FDA researchers or BAM procedures is critical to ensure that performance characteristics of the analytical methods are known and established. Use of officially validated methods ensures accurate and precise laboratory data that will be universally accepted. FDA does have a systematic approach for conducting method validations effectively. Methods must be validated by subjecting them to conditions of actual use in the field in order to measure their fitness of purpose. Food microbiological method validations present unique challenges because of the problems associated with preparation and distribution of the test samples with known, homogeneous and stable microflora. The Moffett Proficiency Testing program consisting of multidisciplinary team of scientists from both FDA and Institute of Food Safety and Health. The team is involved in detecting and quantifying a variety of pathogens/contaminants in foods; validating analytical methods according to latest ISO 16140 series of Standards and FDA, AOAC guidelines. Studies include development of newer protocols for developing homogenous and stable bulk food samples including dry ingredients (nuts, spices, flours and infant formula), fresh produce, dairy products, seafood, and other manufactured foods. Under the guidance of a mentor the participant will be trained in food microbiology and will learn by assisting in laboratory research projects involving bacterial foodborne pathogens. The project will provide diverse experience and training in the areas of food microbiology, including complex assays such as conventional and rapid assays for detection, identification and enumeration of pathogens in food. Throughout the course of the research project, the participant will: Study modern laboratory methods, procedures, data analysis techniques and quality assurance principles. Assist in the development and implementation of laboratory and logistical systems for organizing inter-laboratory method validation based on ISO, FDA and AOAC Standards and guidelines. Develop expertise in techniques to screen a range of food matrices using cultural, biochemical, serological and rapid assays such as immune-assays, PCR and sequencing techniques. Prepare and distribute uniform, homogeneous and stable food samples of variety of matrices and precisely manipulated back ground and different target pathogens ranges according to the study designs. Collect, analyze and summarize inter-laboratory data with detailed method parameters, and analyze the proficiency test and method validation data according to ISO 17043, ISO 13528 and ISO 5725 Standards. Anticipated Appointment Start Date: September 1, 2020 This program, administered by ORAU through its contract with the U.S. Department of Energy to manage the Oak Ridge Institute for Science and Education, was established through an interagency agreement between DOE and FDA. The initial appointment is for one year, but may be renewed upon recommendation of FDA contingent on the availability of funds. The participant will receive a monthly stipend commensurate with educational level and experience. Proof of health insurance is required for participation in this program. The appointment is full-time at FDA in the Bedford Park, Illinois, area. Participants do not become employees of FDA, DOE or the program administrator, and there are no employment-related benefits. Completion of a successful background investigation by the Office of Personnel Management is required for an applicant to be on-boarded at FDA. OPM can complete a background investigation only for individuals, including non-US Citizens, who have resided in the US for a total of three of the past five years. FDA requires ORISE participants to read and sign their FDA Education and Training Agreement within 30 days of his/her start date, setting forth the conditions and expectations for his/her educational appointment at the agency. This agreement covers such topics as the following: Non-employee nature of the ORISE appointment; Prohibition on ORISE Fellows performing inherently governmental functions; Obligation of ORISE Fellows to convey all necessary rights to the FDA regarding intellectual property conceived or first reduced to practice during their fellowship; The fact that research materials and laboratory notebooks are the property of the FDA; ORISE fellow---s obligation to protect and not to further disclose or use non-public information. Qualifications The qualified candidate should have received a masters or doctoral degree in one of the relevant fields. Degree must have been received within five years of the appointment start date. Preferred skills: Advanced level of experience in the areas of food microbiology Skills in interpretation and evaluation of analytical results to determine validity and scientific significance Ability to generate summary reports and manuscript(s), including technical standard operating procedures Excellent verbal and written communication skills Knowledge and experience with laboratory techniques to screen a range of food matrices, including biochemical, serological, rapid detection assays, immuno-assays, Real-Time PCR and other microbial detection and enumeration techniques Experience and research skills such as statistical evaluation and interpretation of laboratory data in validating food analytical methods according to ISO 16140, AOAC and FDA guidelines

Keywords: ORAU Maryland Office, Chicago , Microbiology Fellowship, Other , Bedford Park, Illinois

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